Pharma Materials 99% Purity Pregnenolone Anabolic CAS 145-13-1 White Crystal Raw Powder

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Description

Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.

Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.

Pregnenolone undergoes further steroid metabolism in one of three ways.
Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in production of 17-hydroxy progesterone and andros tenedione, precursor to test osterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandros terone (DH EA) using a desmolase. DH EA is the precursor of andros tenedione.
Pregnenolone can be converted to androsta-5,16-dien-3 beta-ol by 16-ene synthetase.

Effect

Pregnenolone is a natural hormone produced within the body, however many different factors can interfere with proper production of this compound. Natural Pregnenolone production declines as we age. For these reasons, many individuals may benefit from boosting levels of this compound using dietary supplement. When the supplement is taken orally, it is able to quickly pass through the blood-brain barrier and enter into the central nervous system.

Application

Pregnenolone is a steroidal hormone with several powerful nootropic benefits.
It is used as a focus booster, mood enhancer and energy pill. Recent studies have found it effective for improving memory, comprehension, and information processing and critical analysis. According to Dr. Flood of the Geriatric Research Education and Clinical Center, "Pregnenolone is the most potent memory enhancer yet reported". Pregnenolone is also one of the most important hormones within the body, involved in the synthesis of many different types of chemicals and other hormones like androgens, estrogens, glucocorticoids, and more. This supplement is considered to be a pro-hormone, which essentially means that it leads to the production, development, or synthesis of a number of other chemicals and hormones.

Pregnenolone is synthesized from cholesterol. This occurs primarily in the adrenal glands, but also within the liver, skin, brain, testicles, ovaries, and retinas (eye). As a steroid, this supplement acts as a precursor to DHEA, progesterone, testosterone, estrogen, and cortisol. Even though this supplement has some very powerful metabolites, it is also considered to be without significant side effects and very limited anabolic, estrogenic, or androgenic activity.

About US: 

YIHAN INDUSTRIAL Co.,Ltd is a large hight tech chemical enterprise which specialized in fine chemicals, pharmaceutical raw material and intermediates. Our company integrates R&D, producing, operating and marketing into an organic whole.
We are aim to occupy major market share of USA, Canada, UK, Brazil,
Netherlands, Ireland, New Zealand, Austria, Australia, German and worldwide.
Quality is our life! All products produced in Aseptic Laboratory according to GMP standard. Approved the ISO 9001: 2008 and ISO14001: 2004. Besides, we have a complete Q. A. & Q. C. System.

RFQ:

Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.

Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.

Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.

Q5:Do you accept VISA business credit card ?
A:Yes. 

Q6:How long does it take to the goods arrived ?
It is Depending on your location,
For small order, please expect 5-7 days by UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7 Do you have any reshipment policy ?
we have good after-sale service and re-shipment policy if the parcel lose
Our long association with our clients has brought great benefits
We always take the upmost care in the packaging of our products
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship

Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.