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|Standard:||Enterprise Standard||Product Name:||Rimonabant|
|Apperance:||White To Off White Powder||Assay:||99.8% Min|
|Storage:||Shading, Confined Preservation||MW:||463.79|
|Usage:||For Weight Loss||Packing:||Stealth Pack|
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Steroid Powder Acomplia for Weight Loss Bodybuilding Rimonabant 158681-13-1
|Chemical Properties||White to off white powder|
|Usage||Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.|
Rimonabant is one of the most recent drugs created for the treatment of obesity.
This drug acts as a blockade for endocannabinoid receptors found in the brain and peripheral organs that play an important role on carbohydrate and fat metabolism. Clinical studies have confirmed that, when used in combination with a low calorie diet, rimonabant promotes loss in body weight, loss in abdominal circumference, and improvements in dyslipidemia.
Rimonabant is also being tested as a potential anti-smoking treatment since endocannabinoids are related to the pleasurable effect of nicotine. Thus, rimonabant constitutes a new therapeutic approach to obesity and cardiovascular risk factors. Studies show effectiveness in weight loss; however, side effects such as psychiatric alterations have been reported, including depression and anxiety. These side effects have led the FDA (Food and Drug Administration) to not approve this drug in the United States. For a more complete evaluation on the safety of this drug, additional studies are in progress.
|Product Name||Rimonabant||Batch No.||150728|
|Test Items||Specification||Test Results|
|Appearance||Off white crystalline powder||Off white crystalline powder|
|Solubility||Conforms||Freely soluble in methanol|
|T.L.C.||Only one spot||
Only one spot
In a 2006 (2 year) study reported in JAMA, "Compared with the placebo group, the 20 mg of rimonabant group produced greater mean (SEM) reductions in weight (-6.3 kg vs -1.6 [0.2] kg; P<.001), waist circumference (-6.1 [0.2] cm vs -2.5 ] cm; P<.001), and level of triglycerides (percentage change, -5.3 vs 7.9 ; P<.001) and a greater increase in level of high-density lipoprotein cholesterol (percentage change, 12.6 vs 5.4 ; P<.001)."
2) Smoking cessation
Rimonabant may also be found to be effective in assisting some smokers to quit smoking. Sanofi is currently conducting studies to determine the possible value of rimonabant in smoking-cessation therapy. The Studies with Rimonabant and Tobacco Use (STRATUS) program involves more than 6,000 subjects.
Stratus is designed to explore two smoking-related therapies: first, to use rimonabant directly to aid in smoking cessation; second, to help prevent weight gain in former smokers. Initial results apparently suggest rimonabant is effective for both uses. However, the FDA has explicitly stated to Sanofi that, without additional studies, rimonabant cannot be approved in the United States for smoking cessation therapy.
(1) Rimonabant is a weight loss drug, can significantly reduce weight, reduce waist circumference and reduce risk factors for cardiovascular disease, but also can improve blood lipids and insulin resistance and metabolic syndrome,
(2) Rimonabant effective in assisting some smokers to quit smoking
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