Human Growth Hormone Peptide Gonadorelin 2mg Injection CAS71447-49-9

Human Growth Hormone Peptide Gonadorelin 2mg Injection CAS71447-49-9
 

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Product Name: Gonadorelin
Molecular formula: C55H75N17O13.2(C2H4O2)
Molecular weight: 1302.41
CAS NO: 34973-08-5
Active substance: Is a made synthetically LHRH receptors antagonist
Appearance: White powder
Usage: Mainly used for prostate cancer.

Description:

Gonadorelin (also referred to as Gonadorelin Acetate) is a synthetically produced gonadotropin-releasing hormone (GnRH). Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating Gonadorelin hormone and leutinizing hormone from the anterior pitutitary.Gonadorelin
GnRH is available as gonadorelin hydrochloride )and gonadorelin diacetate tetrahydrate for injectable use. Studies have described it being used via an infusion pump Gonadorelin system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.

Factrel (gonadorelin) as a single injection is indicated for evaluating the functional capacity and response of the gonadotropes of the anterior pituitary. This single-injection test does not measure pituitary gonadotropic reserve, for which more prolonged or repeated administration may be required. The LH response is useful in testing patients with suspected gonadotropin deficiency, whether due to the hypothalamus alone or in combination with anterior pituitary failure. Factrel (gonadorelin) is also indicated for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.

In clinical studies to date, however, the single-injection test has not been useful in differentiating pituitary disorders from hypothalamic disorders. The Factrel (gonadorelin) test can be performed concomitantly with other post-treatment evaluations. The results of the Factrel (gonadorelin) test complement the clinical examination and other laboratory tests used to confirm or substantiate hypogonadotropic hypogonadism.

In cases where there is a normal response, it indicates the presence of functional pituitary gonadotropes. The single-injection test does not measure pituitary gonadotropic reserve.

Gonadorelin Fuction:

Gonadorelin is a hormone that is produced naturally by the hypothalamus in the brain. It is also known as gonadotrophin-releasing hormone or GnRH.

Gonadorelin stimulates the pituitary gland in the brain to release the sex hormones luteinising hormone (LH) and follicle stimulating hormone (FSH). In women, FSH stimulates the production of oestrogen and the development of eggs in the ovaries. LH stimulates the ovaries to release an egg (ovulation). In men, LH stimulates the testicles to produce the hormone testosterone and FSH stimulates the testicles to produce sperm.

Gonadorelin is given by injection to check whether the pituitary gland is producing LH and FSH in the correct levels. This can help in the diagnosis of various hormonal disorders, including infertility, delayed puberty and hypogonadism.

 

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