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A new rage in bodybuilding and sports supplements!
One of the hottest topics attracting the attention of athletes, coaches and trainers is the use of the preparation rhEPO (recombinant erythropoietin). EPO (erythropoietin) is a hormone that is naturally produced in the body and is primarily designed to stimulate the production of new red blood cells.
Increasing the number of red blood cells increases the oxygen capacity of the blood to deliver more oxygen for muscle training. These advantages led to the widespread use of synthetic doping-dependent p-REPO preparations.
In connection with the increase in oxygen capacity and other vasoactive effects of interest, the EPO has also become interested in athletes outside the crowd of endurance; Including bodybuilders who want to increase the intensity of exercise, the amount of training sessions and the quality of their training, as well as those who are equally interested in achieving the "eternal pump".
With regard to total dosing, this can be a bit difficult. Epoetin Alfa is usually dosed in the range of 50-100 units per kilogram of body weight in a therapeutic environment. This dose is usually given three times a week and adjusted, based on the indication of the hematocrit level, respectively. For a sportsman with high efficiency, dosing usually begins very low; It does not take long to see a massive result. Many believe that, starting at 10 units per kilogram of body weight, you must be a solid starting point; Sometimes less, sometimes only 5 units per kilogram of body weight. Regardless of the specific dose, three injections per week for two weeks will suffice. This will lead to results, and your account of the number of red blood cells will increase by as much as three months, and maybe longer.
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EPO is produced mainly by peritubular capillary lining cells of the renal cortex; which are highly specialized epithelial-like cells. It is synthesized by renal peritubular cells in adults, with a small amount being produced in the liver.Regulation is believed to rely on a feed-back mechanism measuring blood oxygenation. Constitutively synthesized transcription factors for EPO, known as hypoxia-inducible factors (HIFs), are hydroxylated and proteosomally digested in the presence of oxygen. It binds to the erythropoietin receptor (EpoR) on the red cell surface and activates a JAK2 cascade. This receptor is also found in a large number of tissues such as bone marrow cells and peripheral/central nerve cells, many of which activate intracellular biological pathways upon binding with Epo.
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