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Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding

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Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding

China Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding supplier
Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding supplier Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding supplier Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding supplier

Large Image :  Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding

Product Details:

Place of Origin: CHINA
Brand Name: YIHAN
Certification: ISO 9001, USP
Model Number: GDF-8

Payment & Shipping Terms:

Minimum Order Quantity: 1 box(10vial/box)
Price: US $28.8- $31.5/ vial
Packaging Details: Carton box or as your request
Delivery Time: 5-8 work days
Payment Terms: T/T,MoneyGram
Supply Ability: 10000BOX per month
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Detailed Product Description
Product Name: GDF-8 Specification: 1mg/vial, 10vial/ Box
Other Name: GDF-8 Peptides Grade: Medicine Grade
Sample: Available Form: White Lyophilized Powder Or Sarms Powder
Class: Peptides Suitable For: Adult
Delivered Time: 2-3 Work Days For Small Quantity Business Type: Manufacturer , Factory
Purity: 99% Min Transport Packaging: Discreet Packing Ways
Appearance: White Fine Powder
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Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding  

 

Abstract

 

1. Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

2. Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. There is hope that studies into myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

Application

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.


Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

Free Sample 99% Purity Gdf-8 Growth Hormone Peptides Myostatin For Bodybuilding

COA

 

Item Specification Result
Appearance White powder Complies
Identification Positive Complies
Assay 99.0% min 99. 3%
Loss on Drying 6.0%max. 4.80%
Mass Balance 95.0~105.0% Complies
Acetate Content (HPIC) 12.0%max. 10.80%
Peptide Content (N%) 80.0%min. 88.00%
Amino Acid Composition ±10% of theoretical Complies
Single Impurity (HPLC) 1.0%max. 0.85%

 

Structure and mechanism of action


Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.


Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition. Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

 

Why Choose Us

1.Our payment term:,Money Gram, Bank transfer and PAYPAL.

2.We also offer RESHIP service with free cost if goods were catched by custom.

3.Full experience of large numbers containers loading in Chinese sea port.

4.Raw materials from Chinese origin.

5.Sample(1 vial) is free for you!

 


Our advantage:

1.Our payment term:,Money Gram, Bank transfer and PAYPAL.

2.We also offer RESHIP service with free cost if goods were catched by custom.
3.Full experience of large numbers containers loading in Chinese sea port.
4.Raw materials from Chinese original.

We Promise:

1. Supply you high quality products with a reasonable price.

2. Compensate your loss if our products have quality problems.

3. Arrange the orders and shipment as per your requests in time.

4. Provide complete customs clearance documents according to the import policy of different countries.if custom take away the package we will reship it free shipping cost

5. Provide agile and safe payments.Paypal as well

6. Provide a price trend to ensure you can know about marketing information in time.

7. In a word, we will try our best to solve the problems you encounter.

 

FAQ

Q1. Are you a manufacturer?

Yes, we have our own factory and lab.


Q2. Do you have GMP or other certificates ?

Yes, we have GMP,HSE,ISO 9001,USP certificate for products.


Q3. What information should I let you know if I want to get a quotation?

Answer: -Quality you require, eg. Assay, Purity, or single impurity

-Quantity you need
-Standard you want, such as USP.


Q4. How to make the payment?

We can accept ,Money Gram,Bank Transfer and Paypal as well.


Q5. When will you deliver the goods?

For sample, in about 2 working days after payment; for larger orders (more than 1kg), in about 5 working days after payment.


Q6. How will you deliver the goods?

We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping.
You also can choose your own shipping forwarder.

 

Q7. What if we find your products unsatisfied?

We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.

 

OUR SERVICE

1.Treat every client with sincerity

2.In good faith to make friends .

3.Customer satisfaction is the eternal pursuit

4.Quality is the foundation of survival and development of enterprises

5.We want to work with you to create a better life

 

 

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