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Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3

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Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3

China Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3 supplier
Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3 supplier Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3 supplier Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3 supplier

Large Image :  Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3

Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: ISO 9001
Model Number: 1140909-48-3

Payment & Shipping Terms:

Minimum Order Quantity: 10 Grams
Price: US$8.37-14/ grams
Packaging Details: 1kg/Aluminium Foil Bag or as Required
Delivery Time: 5-8 days
Payment Terms: T/T,MoneyGram
Supply Ability: 1000kg/Month
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Detailed Product Description
Product Name: Cabozantinib Malate CAS NO.: 1140909-48-3
MF: C32H30FN3O10 MW: 635.59
Chemical Character: White Powder Assay: 99%min
Purity: >99% Alias: XL184
Specification: 10g/50g/100g/1kg Transport Package: 1kg/Aluminium Foil Bag Or As Required
Delivery Time: 10-15 Days Door To Door Stock: Mass And Plenty---Prompt Shipment
Export Markets: Global
High Light:

cancer treatment drugs

,

cancer treatment powder

99% Purity Cabozantinib Malate Cancer Treatment Powder CAS 1140909-48-3

 

 

Description

 

Cabozantinib malate is a potent inhibitor of MET andVEGF receptor2 with IC50 values of 1.3nM and 0.035nM.

 

Cabozantinib is a pan-tyrosine kinase inhibitor and is developed as an oral treatment of various cancers including MTC, GBM, NSCLC, pancreatic carcinoma, breast and colon cancer. The targets of cabozantinib are MET, VEGFR-2, RET, FLT3, KIT, AXL as well as TEK. In cellular assays, cabozantinib inhibits the phosphorylation of MET, VEGFR2, KIT, FLT3 and AXL with IC50 values of 7.8, 1.9, 5.0, 7.5 and 42μM, respectively.

 

Specifications

 

Product name Cabozantinib Malate
Alias XL184
CAS 1140909-48-3
MF C32H30FN3O10
MW 635.59
Purity >99%
Assay 99%min
Appearance White powder
Mini Order 10 grams
Package 1kg/Aluminium Foil Bag or as Required
Stock Mass and plenty---Prompt shipment
Payment T/T, , MoneyGram, Bank Transfer ,Paypal
Lead time 5-8 days
Delivery Time 10-15 Days Door to Door
Shipping Option China EMS, EUB, HK Post

 

Applications

 

As a pan-tyrosine kinase inhibitor, cabozantinib can affect many biological processes. Cabozantinib inhibits the tubule formation of HMVEC cells with IC50 value of 6.7nM. In B16F10 cells, cabozantinib inhibits HGF-inducedmigration and invasion with IC50 values of 31nM and 9nM, respectively. Moreover, cabozantinib shows anti-proliferation efficacy in a variety of tumors such as SNU-5, Hs746T, MDA-MB-231 and U87MG. It is also reported that the combination of cabozantinib and gefitinib can cause potent inhibition of the gefitinib-resistant HCC827GR6 cell line.

 

Effects

 

Cabozantinib S-MALATE,formerly known as XL184, trade name Cabometyx, is developed by Exelixis biopharmaceutical company in the United States. The drug is mainly targeted at MET and VEGFR2 tyrosine kinases that associated with the growth and proliferation of prostate cancer, inhibiting tumor metastasis and angiogenesis.

 

Cabozantinib S-MALATE , the malate of Cabozantinib, is an effective VEGFR2 inhibitor, and IC50 is 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2 and AXL, and IC50 is 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM respectively.

 

Cabozantinib(Cometriq) was granted orphan drug status by the U.S. Food and Drug Administration (FDA) in January 2011. Cabozantinib(Cometriq) is approved by the U.S. FDA for medullary thyroid cancer. and advanced renal cell carcinoma in people who have received prior anti-angiogenic therapy. It is currently undergoing clinical trials for the treatment of prostate, bladder, ovarian, brain, melanoma, breast, non-small cell lung, pancreatic, and hepatocellular cancers.

 

Cancer Treatment Powder

 

Product Name CAS NO.
Erlotinib hydrochloride 183319-69-9
Octenidine Dihydrochloride 70775-75-6
Lapatinib Ditosylate 388082-77-7
Gefitinib 184475-35-2
Dasatinib 302962-49-8
Crizotinib 877399-52-5
Ibrutinib 936563-96-1
BIBW2992 DiMaleate 850140-73-7
Cabozantinib Malate 1140909-48-3
lenvatinib Mesylate 857890-39-2
Ceritinib (LDK378) 1032900-25-6
Cabozantinib 849217-68-1
lenvatinib 417716-92-8
Imatinib mesylate 220127-57-1


Competitive Advantages

1 High quality with competitive price:
1) Standard: Enterprise Standard,
2) All Purity≥99%,
3) We are manufacturer and can provide high quality products with factory price.

2 Fast and safe delivery:
1) Parcel can be sent out in 24 hours after payment. Tracking number available,
2) Secure and discreet shipment. Various transportation methods for your choice.

3 We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire,
2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility,
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.

 

Cabozantinib Malate Cancer Treatment Steroids 99% Purity Cas 1140909-48-3

 

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