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Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases

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Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases

China Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases supplier
Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases supplier Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases supplier Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases supplier

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Product Details:

Place of Origin: China
Brand Name: YIHAN
Certification: HPLC
Model Number: YIHAN001

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: USD49-USD1299(10g-500g)
Packaging Details: 10g,50g,100g,500g/Foil Bag or Tin or according to customer's requirement
Delivery Time: 2-5 days
Payment Terms: T/T,MoneyGram
Supply Ability: 10 Kilogram/Kilograms per Month MK-2866 Ostarine
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Detailed Product Description
CAS No: 2627-69-2 MF: C9H14N4O5
Grade Standard: Medicine Grade Usage: Animal Pharmaceuticals
Purity: 99% Min Product Name: AICAR Acadesine
Appearance: Almost White Or White Powder Molecular Weight: 258.23
Shelf Life: 2 Years Purity By HPLC: 99.72%
MOQ: 10G Samples: Available
Payment: TT//Money Gram
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CAS 2627-69-2 Aicar Acadesine Pharmaceutical Raw Materials Treating Cardiovascular Diseases

1. Basic Info


AICA Ribonucleotide (AICAR)

Synonyms: (1) Z-nucleotide

(2) 5-amino-4-imidazolecarboxamide ribotide

(3) aminoimidazole carboxamide ribonucleotide
Storage: Aicar is stable at room temperature for 90 days, It should be stored in a freezer for any extended period of time.
Terms: The products we offer are intended for laboratory research use only. Please familiarize yourself with our Terms and conditions prior to ordering.

Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases

2. Description

(1). AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide.It can also be known as AICA ribonucleotide, ZMP, or Acadesine.It is an intermediate contained in the generation of inosine monophosphate.It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.

(2). AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

(3). AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.

(4). With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion.Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.


3. How AICA Ribonucleotide Works


According to scientific study that has been based on animal test subjects, AICA Ribonucleotide's functionality is linked to preventing the production of the enzymes Adenosine kinase (ADK) and Adenosine deaminase (ADA). This process ultimately acts to stimulate glucose uptake and boost the activity of p38 mitogen-activated protein kinases α and β in skeletal and muscular tissue.


Along the way, it has been shown to block apoptosis by lowering the production of oxygen compounds that are located within the cell. These processes ultimately lead to boost in blood flow regulation, which in turn enables an animal test subject to experience an improved rate of homeostasis.


4. Functions


(1). AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.

(2). Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).

(3). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

5. Biological Activity

(1). AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

(2). Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.


6. AICA Ribonucleotide and Improved Processes


AICA Ribonucleotide's functionality has allowed scientific study that has been based on animal test subjects has been able to determine that the peptide could be responsible for several boosted functional processes, such as a boost of endurance and an increase at the rate adipose tissue is broken down. It has also been determined that the peptide's capacity to increase blood flow can allow it to be a theoretic treatment in the aftermath of an ischemic injury.


Analysis Report


Specification Result
Appearance White powder Complies
Related substance (HPLC) Total impurity ≤0.5%
Max single impurity ≤0.1%
Odor Characteristic Complies
Assay 99% 99.8%
Sieve analysis 100% pass 80 mesh Complies
Loss on Drying
Residue on Ignition
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies

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We Promise:

1. Supply you high quality products with a reasonable price.
2. Compensate your loss if our products have quality problems.
3. Arrange the orders and shipment as per your requests in time.
4. Provide complete customs clearance documents according to the import policy of different countries.if custom take away the package we will reship it free shipping cost
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7. In a word, we will try our best to solve the problems you encounter.


Product name CASNo. Specification
Ostarine(MK2866) 841205-47-8/1235370-13-4/1202044-20-9 99%min
LGD-4033 1165910-22-4 98%min
MK-677 159633-92-8 98%min
Andarine(S-4) 401900-40-17 98%min
GW 501516 317318-70-0 98%min
RAD140 1182367-47-0 98%min
SR9009 1379686-30-2 98%min
YK11 1370003-76-1 98%min

Aicar Acadesine Pharmaceutical Raw Materials CAS 2627-69-2 For Cardiovascular Diseases
Q1. Are you a manufacturer?
Yes, we have our own factory and lab.
Q2. Do you have GMP or other certificates ?
Yes, we have GMP,HSE,ISO 9001,USP certificate for products.
Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP.
Q4. How to make the payment?
We can accept ,Money Gram,Bank Transfer and Paypal as well.
Q5. When will you deliver the goods?
For sample, in about 2 working days after payment; for larger orders (more than 1kg), in about 5 working days after payment.
Q6. How will you deliver the goods?
We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping.
You also can choose your own shipping forwarder.
Q7. What if we find your products unsatisfied?
We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
If you want more details, please feel free to contact me. Welcome.

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