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|Grade Standard:||Medicine Grade||Usage:||Animal Pharmaceuticals|
|Purity:||99% Min||Product Name:||AICAR Acadesine|
|Appearance:||Almost White Or White Powder||Molecular Weight:||258.23|
|Shelf Life:||2 Years||Purity By HPLC:||99.72%|
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CAS 2627-69-2 Aicar Acadesine Pharmaceutical Raw Materials Treating Cardiovascular Diseases
1. Basic Info
AICA Ribonucleotide (AICAR)
Synonyms: (1) Z-nucleotide
(2) 5-amino-4-imidazolecarboxamide ribotide
(3) aminoimidazole carboxamide ribonucleotide
Storage: Aicar is stable at room temperature for 90 days, It should be stored in a freezer for any extended period of time.
Terms: The products we offer are intended for laboratory research use only. Please familiarize yourself with our Terms and conditions prior to ordering.
(1). AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide.It can also be known as AICA ribonucleotide, ZMP, or Acadesine.It is an intermediate contained in the generation of inosine monophosphate.It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.
(2). AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
(3). AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.
(4). With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion.Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.
3. How AICA Ribonucleotide Works
According to scientific study that has been based on animal test subjects, AICA Ribonucleotide's functionality is linked to preventing the production of the enzymes Adenosine kinase (ADK) and Adenosine deaminase (ADA). This process ultimately acts to stimulate glucose uptake and boost the activity of p38 mitogen-activated protein kinases α and β in skeletal and muscular tissue.
Along the way, it has been shown to block apoptosis by lowering the production of oxygen compounds that are located within the cell. These processes ultimately lead to boost in blood flow regulation, which in turn enables an animal test subject to experience an improved rate of homeostasis.
(1). AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.
(2). Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).
(3). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
5. Biological Activity
(1). AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
(2). Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.
6. AICA Ribonucleotide and Improved Processes
AICA Ribonucleotide's functionality has allowed scientific study that has been based on animal test subjects has been able to determine that the peptide could be responsible for several boosted functional processes, such as a boost of endurance and an increase at the rate adipose tissue is broken down. It has also been determined that the peptide's capacity to increase blood flow can allow it to be a theoretic treatment in the aftermath of an ischemic injury.
|Related substance (HPLC)||Total impurity ≤0.5%
Max single impurity ≤0.1%
|Sieve analysis||100% pass 80 mesh||Complies|
|Loss on Drying
Residue on Ignition
|Total Plate Count||<1000cfu/g||Complies|
|Yeast & Mold||<100cfu/g||Complies|
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Yes, we have our own factory and lab.
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Yes, we have GMP,HSE,ISO 9001,USP certificate for products.
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